GLP-3 — RETA (Retatrutide)

SKU: GLP-3-RETA   |   Category: GLP Series

Triple GIP/GLP-1/glucagon receptor agonist | Lyophilized | ≥99% purity

Retatrutide (LY3437943) is a synthetic acylated peptide functioning as a triple agonist at GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors. Its trimodal mechanism of action distinguishes it from dual-agonist analogs, engaging distinct downstream signaling pathways implicated in energy homeostasis, adipose regulation, and metabolic substrate utilization.

Molecular studies have examined retatrutide’s binding kinetics and receptor selectivity profiles across all three target receptors. In vitro research has focused on its effects on cAMP accumulation, insulin secretion in pancreatic beta cell models, and lipid mobilization in adipocyte cultures. Preclinical models have explored its pharmacokinetic profile, including half-life extension via fatty acid acylation and albumin binding.

Each vial is lyophilized under inert gas and manufactured in ISO 9001 certified facilities. Purity is independently verified at ≥99% by HPLC via ISO/IEC 17025 accredited third-party laboratories. COA available on the RIVN Peptides testing page.

Storage: Store lyophilized powder at -20°C. Once reconstituted, store at 4°C and use within 28 days.

⚠ For laboratory research use only. Not for human or animal consumption.