TESAMORELIN

SKU: TESAMORELIN   |   Category: Research Compounds

Trans-3-hexenoic acid-modified GHRH(1-44) | Stabilized GH-releasing factor | ≥99% purity

Tesamorelin is a synthetic analog of human growth hormone-releasing hormone (hGHRH) consisting of the full 44-amino acid sequence of GHRH with a trans-3-hexenoic acid moiety conjugated to the N-terminus. This modification improves stability against dipeptidyl peptidase IV (DPP-IV) cleavage at the His-Ala N-terminal bond, significantly extending the compound’s half-life in plasma versus unmodified GHRH in pharmacokinetic studies.

Research applications include GHRHR binding and activation assays, comparative pharmacokinetic profiling versus unmodified GHRH(1-44) and truncated analogs such as sermorelin (GHRH 1-29), investigation of DPP-IV-mediated proteolytic cleavage mechanisms, somatotroph GH synthesis and secretion modeling, and metabolic profiling in cell culture models examining the downstream effects of sustained GHRH receptor activation on lipid metabolism gene expression.

Available in 5mg and 10mg vials, lyophilized. Manufactured in ISO 9001 certified, GMP-compliant facilities. Purity independently verified at ≥99% by HPLC via ISO/IEC 17025 accredited laboratory. Full COA available.

Storage: Store lyophilized at -20°C. Reconstituted: 4°C, use within 21 days.

⚠ For laboratory research use only. Not for human or animal consumption.