TB-500 10MG

SKU: TB500-10MG   |   Category: Regenerative

Thymosin Beta-4 active fragment | Actin-sequestering peptide | ≥99% purity

TB-500 refers to the biologically active fragment of Thymosin Beta-4 (Tβ4), a 43-amino acid G-actin sequestering protein ubiquitously expressed in mammalian cells. The active fragment (typically the central actin-binding domain) retains the core LKKTETQ motif responsible for G-actin binding, modulating the ratio of monomeric (G-actin) to filamentous (F-actin), a balance critical for cell motility, wound contraction, and angiogenic sprouting.

Research applications include actin dynamics studies (G-actin binding assays, barbed-end elongation inhibition), endothelial cell migration and tube formation assays in Matrigel angiogenesis models, myofibroblast differentiation studies, investigation of Tβ4-mediated upregulation of integrin-linked kinase (ILK) and downstream Akt activation, and cardiac repair research using cardiomyocyte culture systems. TB-500 has an extensive literature base in rodent models of tissue repair.

10mg lyophilized per vial. Manufactured in ISO 9001 certified, GMP-compliant facilities. Purity confirmed at ≥99% by HPLC via ISO/IEC 17025 accredited laboratory. COA on file.

Storage: Store lyophilized at -20°C. Reconstituted: 4°C, use within 28 days.

⚠ For laboratory research use only. Not for human or animal consumption.