GLP-1 — SEMA (Semaglutide)

SKU: GLP-1-SEMA   |   Category: GLP Series

GLP-1 receptor agonist | C18 fatty acid acylated | Lyophilized | ≥99% purity

Semaglutide is a 31-amino acid GLP-1 analog with a C18 fatty diacid side chain attached via a linker to lysine at position 26. This modification confers high albumin affinity and substantially extends plasma half-life relative to native GLP-1 in pharmacokinetic models. The compound demonstrates high selectivity for the GLP-1 receptor (GLP-1R), a class B GPCR expressed in pancreatic, cardiovascular, neurological, and gastrointestinal tissues.

Research applications include GLP-1R activation assays, competitive receptor binding studies, signaling pathway analysis (cAMP, ERK1/2, beta-arrestin recruitment), and structure-activity relationship comparisons with shorter-acting GLP-1 analogs. Its stability profile makes it particularly suitable for extended in vitro incubation protocols.

Produced in ISO 9001 certified facilities under GMP standards. Purity verified at ≥99% by HPLC through ISO/IEC 17025 accredited third-party testing. Full COA available.

Storage: Store lyophilized at -20°C. Reconstituted: 4°C, use within 28 days.

⚠ For laboratory research use only. Not for human or animal consumption.